This game is funky: it has 2 different saves. The game saves based on 'progress' for story and when you end for 'inventory'. If you're worried about items (like in Zealot difficulty) you can exploit this for lots of items around Scav Dopplers!

Thank you for reminding me, Fun Fact: beating the game on the highest difficulty unlocks The Finger/Devil Horns, a Foam Finger you can use as a weapon. Shooting it makes your character go 'PEW BANG' and is a one-shot on regular Necros! Really goofy!